| Name | Description | Found | Price |
| ANTIDOTE | Cures poison | PokéMart Virdian Forest |
100 |
| AWAKENING | Cures sleep | PokéMart Pokémon Tower |
250 |
| BICYCLE | Allows you to travel faster | Cerulean Bike Shop | 1 million |
| BIKE VOUCHER | Used to get a FREE Bike | Vermillion Pokémon Fan Club | |
| BURN HEAL | Heals burns | PokéMart | 250 |
| CALCIUM | Increases Special level | Silph Co. Route 13 Pokémon Mansion Celadon Dept. Store |
9800 |
| CARBOS | Increases Speed level | Silph Co. Safari Zone Power Plant Pokémon Mansion Celadon Dept. Store |
9800 |
| CARD KEY | Unlocks Silph Co. doors | Silph Co. 5th Floor |
|
| COIN | Slot Machine money | Game Corner | 50 |
| COIN CASE | Holds coins | Celadon 'Resturant' | |
| DIRE HIT | Increases attack effectiveness | Celadon Dept. Store | |
| DOME FOSSIL | Changes into Kabuto | Mt. Moon | |
| ELIXER | Gives 10 PP to all Attacks | Pokémon Tower | |
| ESCAPE ROPE | Used to escape an area | Pokémart Mt. Moon Game Corner Pokémon Tower Silph Co. Pokémon Mansion |
550 |
| ETHER | Gives 10 PP to one Ability | Different Areas S.S. Anne |
|
| EXP. ALL | Shares experience points | Route 15 | |
| FIRE STONE | Evolves some Fire Pokémon | Celadon Dept. Store | 2100 |
| FRESH WATER | Quenches thirsts Restores 50 HP |
Celadon Dept. Store Roof | 200 |
| FULL HEAL | Cures any ailments | PokéMart Silph Co. Victory Road |
600 |
| FULL RESTORE | Cures any ailments Restores all HP |
PokéMart Safari Zone Pokémon Mansion 2 in Cerulean Cave |
3000 |
| GOLD TEETH | Helps Warden to Speak | Safari Zone 3 | |
| GOOD ROD | Used to fish | Fuchsia City | |
| GREAT BALL | More Effective than a Pokéball | PokéMart S.S. Anne |
600 |
| GUARD SPEC. | Disables Special Attacks | Celadon
Dept. Store Victory Road |
700 |
| HELIX FOSSIL | Changes into Omanyte | Mt. Moon | |
| HP UP | Increases HP by 1 | Route 2 Mt. Moon Game Corner Celadon Dept. Store Pokémon Tower Silph Co. Power Plant |
|
| HYPER POTION | Restores 200 HP | PokéMart Game Corner Silph Co. |
1500 |
| ICE HEAL | Heals frozen Pokémon | PokéMart | 250 |
| IRON | Increases Defense level | Game Corner Route 12 Pokémon Mansion Celadon Dept. Store |
9800 |
| ITEM FINDER | Finds Hidden Items | Route 11 | |
| LEAF STONE | Evolves some Grass Pokémon | Celadon Dept. Store | 2100 |
| LEMONADE | Quenches thirst Restores 80 HP |
Celadon Dept. Store Roof | 350 |
| LIFT KEY | Activates Game Corner Elevator | Game Corner | |
| MASTER BALL | Catches Pokémon 100% of time | Silph Co. | |
| MAX ELIXER | Restores all PP | Various Areas Cerulean Cave |
|
| MAX ETHER | Restores all PP of 1 ability | Various Areas S.S. Anne |
|
| MAX POTION | Restores all HP | PokéMart S.S. Anne 2 in Safari Zone Pokémon Mansion |
2500 |
| MAX REPEL | Prevents wild Pokémon from attacking | PokéMart | 700 |
| MAX REVIVE | Revives Restores all HP |
Silph Co. Safari Zone Victory Road Cerulean Cave |
|
| MOON STONE | Evolves some Pokémon | 2 in Mt. Moon Route 2 Game Corner Pokémon Mansion |
|
| NUGGET | Sold for 5000 | Various Areas Nugget Bridge Game Corner Pokémon Tower Safari Zone Cerulean Cave |
|
| OAK'S PARCEL | Exchange for Pokédex | Virdian City-PokéMart | |
| OLD AMBER | Changes into Aerodactyl | Pewter City-Museum | |
| OLD ROD | Fish for Magicarp | Vermillion City | |
| PARALYZE HEAL | Heals Paralysis | PokéMart | 200 |
| POKÉBALL | Lowest odds of catching Pokémon | PokéMart Viridian Forest |
200 |
| POKÉDEX | Records Pokémon Data | Pallet Town | |
| POKÉDOLL | Distracts Opponents Makes girls happy |
Celadon Dept. Store | 1000 |
| POKÉFLUTE | Wakes sleeping Pokémon | Pokémon Tower | |
| POTION | Restores 20 HP | PokéMart Pallet Town Route 1 Viridian City Viridian Forest 2 in Mt. Moon |
300 |
| PP UP | Increases PP by 1 | Various Areas Cerulean Cave |
|
| PROTEIN | Increases Attack level | Celadon
Dept. Store Silph Co. Route 13 Safari Zone |
9800 |
| RARE CANDY | Increases Exp Level by 1 | Mt. Moon Cerulean City S.S. Anne Game Corner Pokémon Tower Silph Co. Power Plant Pokémon Mansion Victory Road Cerulean Cave |
|
| REPEL | Prevents wild Pokémon from attacking | PokéMart | 350 |
| REVIVE | Revives fainted Pokémon | PokéMart | 1500 |
| S.S. TICKET | Used to Board S.S. Anne | Sea Cottage | |
| SAFARI BALL (30) | Used in Safari Zone | Safari Zone | 1000 |
| SECRET KEY | Unlocks Cinnabar Island Gym | Pokémon Mansion | |
| SILPH SCOPE | Used to identify Ghosts | Game Corner | |
| SODA POP | Quenches Thirsts Restores 60 HP |
Celadon Dept. Store Roof | 300 |
| SUPER POTION | Restores 50 HP | PokéMart Game Corner |
700 |
| SUPER REPEL | Prevents wild Pokémon from attacking | PokéMart | 500 |
| SUPER ROD | Fishes for Pokémon | Route 12 | |
| THUNDER STONE | Evolves Pikachu | Celadon Dept. Store | 2100 |
| TOWN MAP | Shows you where you are | Rival's House | |
| ULTRA BALL | Better than Great Balls | PokéMart 2 in Cerulean Cave |
1200 |
| WATER STONE | Evolves some water Pokémon | Celadon Dept. Store | 2100 |
| X ACCURACY | Boosts Accuracy Temporarily | Pokémon
Tower Silph Co. Celadon Dept. Store |
950 |
| X ATTACK | Boosts Attack Temporarily | Celadon Dept. Store | 500 |
| X DEFEND | Boosts Defense Temporarily | Celadon Dept. Store | 550 |
| X SPECIAL | Boosts Special Temporarily | Celadon Dept. Store | 350 |
| X SPEED | Boosts Speed Temporarily | Celadon Dept. Store | 350 |
