The first encounter with Team Plasma is within Floccesy Ranch. Upon your first entry there you will learn that a Herdier is missing. As you look for it, you discover it has been taken by a Team Plasma member who gives you TM21 in order to convince you not to tell people that they were there.

You will next encounter Team Plasma as you go to leave Virbank City. Several grunts will be at the pier and will inform you that they intend to take over the world after their plans failed two years ago. Deciding that they want to steal your Pokémon, they challenge you to the first battle. Once you defeat them, they run off to Route 20 to challenge more grunts. After defeating them, they escape with your rival thinking they may be at Castelia City

When trying to go to the Castelia City Gym, you will meet with Iris who will inform you that Burgh has run off to Castelia Sewers to deal with an incident. This incident features Team Plasma. As you enter, your rival joins you as you go through and defeat all of the grunts. Once defeated, you'll meet Colress for the first time. He'll leave after thanking you for the entertaining battle

You then meet Colress at the Castelia Central Area where he will mention how well treated your Pokémon seem to be and that he is researching the strength behind Pokémon.

When going through Route 4, you will see that the path in front of you is blocked by a swarm of Crustle. Colress will quickly appear and tell you that he can move the Pokémon, which he manages to do. He then challenges you and gives you a Protein once you have defeated him

Pokémon Trainer Colress	Magnemite	Klink
Battle Type Items	Level 21	Level 23
	Attacks: Sonicboom Thunder Wave Magnet Bomb Spark	Attacks: Charge Thundershock Gear Grind Bind
	Hold Item: No Item	Hold Item: No Item

After defeating the Nimbasa City Gym, the next encounter with Team Plasma is at the north of Nimbasa City where youinterrupt them fighting with your rival. Here, your rival has a go at them for stealing the Purrloin he was going to give to his sister. Team Plasma state that they will continue to steal Pokémon and the grunts challenge you.

As you enter Driftveil City, you will encounter two Team Plasma members, one in their new uniform and one in their old one. The two members are having a difference of opinion with the old Plasma member suggesting that N wouldn't approve of Team Plasma's current mission to which the new Plasma member suggests that N was a traitor to the cause. Your rival appears and chases off the new Plasma member. The old Plasma member explains that the team split into two following the defeat of Ghetsis two years prior. He will take you to see one of Team Plasma's seven sages who will test your strength with a battle.

Pokémon Trainer Rood	Herdier	Swoobat
Battle Type Items	Level 27	Level 27
	Attacks: Helping Hand Take Down Work Up Crunch	Attacks: Heart Stamp Imprison Air Cutter Attract
	Hold Item: No Item	Hold Item: No Item

After defeating him, he'll give you more of the history of Team Plasma, but your rival interrupts and blames old Team Plasma for the theft of his Purrloin. As a form of apology, Rood gives you a Zorua, previously owned by N

As you leave the Pokémon World Tournament, a Team Plasma grunt will run past you, your rival and Cheren. Deciding to make chase, Colress appears and questions why the rival is angry with Team Plasma. As you follow the grunt, you find yourself on board the Team Plasma Frigate, a massive boat filled with Plasma grunts. As you enter, you, Cheren and your rival get cornered and have to face off numerous grunts. Once you've taken out numerous grunts, another Plasma sage, Zinzolin, appears and mentions that they seek to awaken the power of the Legendary Dragon to control Unova and calls the Shadow Triad who teleport you away.

Having been sent to Opelucid City by Professor Juniper who wishes you to find out about the Legendary Dragon Pokémon from Drayden, you will next encounter Team Plasma in Lacunosa Town. Afterl earning the history of how Kyurem arrived in the Giant Chasm, your rival will appear, once again looking for Team Plasma. When he arrives, the Plasma Sage Zinzolin appears once again and challenges you in a Double Battle with another Grunt.

Team Plasma Zinzolin	Cryogonal	Sneasel
Battle Type Items	Level 42	Level 44
	Attacks: Ice Beam Light Screen Reflect Slash	Attacks: Screech Slash Snatch Punishment
	Hold Item: No Item	Hold Item: No Item

After defeating Drayden in the Opelucid Gym, he will start telling you about the Legendary Dragon Pokémon. As he begins, Team Plasma's Frigate appears in the sky and will take fire at the city using a powerful ice beam which freezes the city and surrounding area.. Drayden tries to smash the ice, but to no avail so sstates you have to chase after the Team Plasma members here and defeat them.

As you progress through the frozen city, you need to defeat Team Plasma grunts. Eventually, you'll face up against Zinzolin once again.

Team Plasma Zinzolin	Cryogonal	Cryogonal	Weavile
Battle Type Items	Level 46	Level 46	Level 48
	Attacks: Ice Beam Reflect Slash Confuse Ray	Attacks: Ice Beam Light Screen Slash Confuse Ray	Attacks: Night Slash Slash Ice Shard Metal Claw
	Hold Item: No Item	Hold Item: No Item	Hold Item: No Item

Defeat Zinzolin and Drayden will give you the DNA Splicers to aid you in your quest. However, as he does, the Shadow Triad appear and steal the item. You make chase, being able to battle one of them. When you have defeated them, your rival will call you and say that you should investigate them around Humilau City.

Team Plasma Shadow	Pawniard	Pawniard	Absol
Battle Type Items	Level 46	Level 46	Level 48
	Attacks: Metal Claw Faint Attack Slash Scary Face	Attacks: Metal Claw Faint Attack Slash Hone Claws	Attacks: Night Slash Slash Future Sight Swords Dance
	Hold Item: No Item	Hold Item: No Item	Hold Item: No Item

When you reach the city, you will learn that Team Plasma's Frigate has been spotted nearby and that you should look for Marlon, the local Gym Leader, for assistance. After defeating him in the gym, he says he will help and leaves towards Route 21. When you go there and enter the Seaside Cave, you will find your path blocked by a Crustle. Go to Route 22 and you'll encounter Colress by Terrakion. Colress will ask you if you intend to fight Team Plasma, and if you do, he'll give you his machine, the Colress Machine, to aid in your quest.

Return to the Seaside Cave and you'll be able to use the Colress Machine in order to remove the Crustle from your path. This will allow you access to the coast where Team Plasma is docked. Marlon will appear, having been able to activate the bridge that connects the ship to the coast and allows you to enter. As you go in, you have to defeat numerous grunts and participate in a warp tile puzzle to enter the final room of the frigate where Kyurem is being stored and used as an energy source. Zinzolin will appear once again and challenge you and your rival in a double battle with a grunt again.

Team Plasma Zinzolin	Cryogonal	Cryogonal	Weavile
Battle Type Items	Level 48	Level 48	Level 50
	Attacks: Ice Beam Reflect Slash Confuse Ray	Attacks: Ice Beam Light Screen Slash Confuse Ray	Attacks: Night Slash Slash Ice Shard Metal Claw
	Hold Item: No Item	Hold Item: No Item	Hold Item: No Item
Route 21 Entry

Defeat him and your rival will state that the Liepard that the grunt used was the Purrloin that was stolen from him a long time ago. The sage states that they won't fail this time and once again, calls for the Shadow Triad to dispose of you. When you awaken on the coast, Cheren will appear and mention that Team Plasma have been spotted in the Giant Chasm

When you enter the Giant Chasm, you will learn that a spy from old Team Plasma is in new Team Plasma, the grunt met in Driftveil City, and he has cleared the way into the Giant Chasm for you. As you go in, you'll meet with Rood who will state that he is trying to negotiate with new Team Plasma to follow N's ideals, but new Team Plasma state that they do not listen to traitors. After defeating several grunts, you're able to pass as Rood continues to negotiate. Go in and you have to enter the Plasma Frigate once again.

This time, as you go through the Frigate, you go through the basement where you have to defeat numerous Plasma Grunts in order to obtain a password to open the door. This password is from a random and so you need to battle the Plasma grunts to get hints as to what the password could be. Once you make your way through, you'll see Kyurem in the core again and move onto the helm of the ship where Colress is. Colress states that his intent has been to learn about the strengths of Pokémon so he joined Team Plasma regardless of the consequences to the world. He challenges you.

Team Plasma Colress	Magneton	Metang	Beheeyem	Magnezone	Klinklang
Battle Type Items	Level 50	Level 50	Level 50	Level 50	Level 52
	Attacks: Volt Switch Flash Cannon Tri Attack Thunder Wave	Attacks: Meteor Mash Zen Headbutt Rock Slide Agility	Attacks: Psychic Energy Ball Calm Mind Recover	Attacks: Discharge Flash Cannon Explosion Thunder Wave	Attacks: Gear Grind Thunderbolt Giga Impact Shift Gear
	Hold Item: Eviolite	Hold Item: No Item	Hold Item: No Item	Hold Item: No Item	Hold Item: Air Balloon

Once you've defeated him, he'll give you clearance to go to Ghetsis' room since he wants to see you defeat him. As you enter, Ghetsis explains that he wishes to freeze all of Unova so that Team Plasma can steal all of the Pokémon within the region and that Kyurem is an empty existance. The remainder when a certain Pokemon was split into Reshiram and Zekrom. As such, he will pour all of his ambition into the empty shell that is Kyurem. He will soon leave and send the Shadow Triad at you while they give the rival the Liepard that used to be his Pokémon.

Team Plasma Shadow	Pawniard	Pawniard	Absol
Battle Type Items	Level 49	Level 49	Level 51
	Attacks: Metal Claw Faint Attack Slash Scary Face	Attacks: Metal Claw Faint Attack Slash Hone Claws	Attacks: Night Slash Slash Future Sight Swords Dance
	Hold Item: No Item	Hold Item: No Item	Hold Item: No Item
Giant Chasm Entry

Team Plasma Shadow	Pawniard	Pawniard	Accelgor
Battle Type Items	Level 49	Level 49	Level 51
	Attacks: Metal Claw Faint Attack Slash Scary Face	Attacks: Metal Claw Faint Attack Slash Hone Claws	Attacks: Bug Buzz Giga Drain Swift Me First
	Hold Item: No Item	Hold Item: No Item	Hold Item: No Item
Giant Chasm Entry

Team Plasma Shadow	Pawniard	Pawniard	Banette
Battle Type Items	Level 49	Level 49	Level 51
	Attacks: Metal Claw Faint Attack Slash Scary Face	Attacks: Metal Claw Faint Attack Slash Hone Claws	Attacks: Shadow Claw Sucker Punch Psychic Will-o-wisp
	Hold Item: No Item	Hold Item: No Item	Hold Item: No Item
Giant Chasm Entry

After defeating the Shadow Triad, you can exit the Plasma Frigate and go into the deep cave where Kyurem dwells. Inside the cave, you will find Kyurem and Ghetsis. Ghetsis will explain that the Giant Chasm is Kyurem's strongest place and that he will be able to complete his plans from here. However, as he proceeds, N appears with his Pokémon and attempts to stop Ghetsis, stating that he likes the Unova region and refuses to see Pokémon suffer at the hands of a man. However, Ghetsis interrupts by causing Kyurem to merge with N's Pokémon. Once Kyurem has changed form, it will challenge you. However, Ghetsis' device blocks the use of PokéBalls so it cannot be captured. Once defeated, Kyurem will seperate nto its base form and N's Pokémon once again after plees from N

After doing so, Ghetsis will be angered and will challenge you to a battle.

Team Plasma Ghetsis	Cofagrigus	Seismitoad	Eelektross	Drapion	Toxicroak	Hydreigon
Battle Type Items	Level 50	Level 50	Level 50	Level 50	Level 50	Level 52
	Attacks: Protect Shadow Ball Toxic Psychic	Attacks: Muddy Water Sludge Wave Earthquake Drain Punch	Attacks: Thunderbolt Crunch Flamethrower Acrobatics	Attacks: Night Slash Earthquake Poison Fang X-scissor	Attacks: Poison Jab Sucker Punch Shadow Ball Brick Break	Attacks: Dragon Rush Crunch Rock Slide Frustration
	Hold Item: Leftovers	Hold Item: No Item	Hold Item: No Item	Hold Item: No Item	Hold Item: No Item	Hold Item: Life Orb

Once defeated, Ghetsis will be shocked at the occurance, unsure why the Pokémon aren't proving his strength since he considers them to be tools. N requests that he stops, but Ghetsis refuses and leaves, leaving his staff in the cave. N will thank you for your assistance and your rival will appear, stating that Team Plasma have flown off on their frigate.

After you have defeated the Elite Four, you'll be able to find Team Plasma's Frigate docked at the P2 lab. When in there, Colress will mention that he has stopped working for Team Plasma and is there to atone for his actions. The Plasma members on the boat agree and stay there to try and change their ways. Colress is battleable every day, though he will move to the deck of the ship.

Pokémon Trainer Colress	Magneton	Rotom	Metagross	Beheeyem	Magnezone	Klinklang
Battle Type Items	Level 72	Level 72	Level 72	Level 72	Level 72	Level 74
	Attacks: Volt Switch Flash Cannon Tri Attack Thunder Wave	Attacks: Discharge Hydro Pump Will-o-wisp Substitute	Attacks: Meteor Mash Zen Headbutt Rock Slide Agility	Attacks: Psychic Energy Ball Calm Mind Recover	Attacks: Thunderbolt Flash Cannon Hyper Beam Thunder Wave	Attacks: Gear Grind Wild Charge Giga Impact Shift Gear
	Hold Item: Eviolite	Hold Item: Life Orb	Hold Item: Muscle Band	Hold Item: Leftovers	Hold Item: Wise Glasses	Hold Item: Air Balloon
P2 Lab Entry

In addition to this, old Team Plasma are still in Driftveil City, waiting for N to make a return. Your rival returns there and apologies for his attitude towards them, stating that the theft of his Purrloin was not their fault.